BBe/leHHe

PenponyKTUBHasi CUCTeMa NpejHazHauyeHa
_ A1 BOCHPOU3BEAEHHU o
Tougzgg,rgnmeumunu iy nn? BblHAIIMBaHUA TM/a04a . Y a ity
JIOUZIEHTHUYEeH (MNoJayasiJIoOTeHEeH) MO OTHOMEeHHD K
MaTepuHC-
xgny OPraHu3My, TIOCKOJIbKY OH COAEpXUT NOJMOBUHY reHeTuqecxg vy -
§OPOHH0FO MaTephana, HacC/eAOBAHHOI'O OT OTUa. AHTHUCEeHb OTLOBCKO-
u“"nggggggfifiggzfln;gfigggngfi AJsl OpraHUu3Ma XeHWWHH . [lpyu UMNJIaHTa-
AUT CeHCUOHAU3a :
oy i Uusl OpraHu3Ma MaTepu K
[lnajeHTa 4YesoBeKa ¥ IWiof pa '
2H CCMaTPHBANTCsA HWMMYHOJIOTaMM Kak
:figég:gggnaggKgugngnoruqecxoro anaorpaflcnnaurara,y a HeoTTopXe-
st Y, ‘ YXEpPONHOro njoxa - ¥MMMYHOJOTHYECKUMM fapajok-
BO3MOXHOCTb HOPMafibHOM GYHKLHUU /
‘ enpoAyKTUBHON CHUCTEMH 350~
ggggfiufiggfigg ggggggggoro nepuoga ogecneqnaaercs HaJIu4unemM ynnfiy—
M HOpPMa/bHbIM HKLMOHUpPOBA -
ryn?ropnux MeXaHU3MOB. "p i 3 i i
MIIOTaMaMO-TMNOPU3apHO-TOHAZIHAS OCb HAXOJAUTCHA B pel
. UTIPOKTHOM
OTHOILIEHWH C HMMYHHOHW CHUCTeMOW. XOTS TI'OHAJO3KTOMUSA (Kacgpauufl)
HE OKa3bBaeT CYNeCTBeHHOIO BJIMAHUS Ha HMMYHHYI0 CUCTEMY, TeM He
MeHee MNPpOHUCXOAHUT HeKOTOopas CTUMYJSILUS pocTa TUMyCa U Cefe3eHKH.
/2/ PapMakKo/IoTUYeCKHe [O3h DCTPOreHOB H AHAPOreHOB BH3HBAKT
CHMXeHUe MaCCh THMyca, axKTUBHOCTH auMMpoLUTOB. /3/ ACTPOreHn u
AHAPOTr'eHb HeraTHBHO KOHTPOJIMPYIT ypOBeHb M/I-6 - MONMHOro CTHUMy-
AATOpa TMNOTAJMAMO-TMNOQH3apHO-HAANIOYEYHUKOBON ocu. (WU/-6 urpaer
HEeHTPaJ/IbHYID POJIb B INaTOr€He3e OCTeolnopo3a 3a CUYeT YCHU/IEeHUS Co3-
PeBaHHA OCTEeOKJ/IaCTOB - TKaHeBHX MaKkpogaroB KoCTU. /4
B penpoAyKTUBHOW CHCTEME KaK MyX4YMH, Tak W XEHHUH MOXeT pas-
BHMBAaTbCH MMMYHHBIY OTBET. AHTWUIeH He Bhi3bBaeT MMMYHHBIH OTBEeT B
ClydasaXx PAa3BAUTUA TOMEPAHTHOCTM Ha AAaHHbBM AHTUCEeH U INpPU YHUUTO-
XE€HUM B HMMMYHONPHWBW/IETHPOBAaHHHX opraHax T-xeanepos (Th). Ipen-
rnojaraercs, YTO B CEeMEeHHUKaX, MaTKe M MNaaugeHTe HMMYHO/NOorUYecKas
NMPMBHU/IErMPOBAHHOCThL YyCTAaHaB/MBAeTCs 3a CYeT DBKCNpPeCCUM LIUTOTOK-
CHYeCKHX MOJIeKyJ/, FaslL Ha KaeTkax, oTjpe/sioljuX KpOoBb U AUMpaTH-
YeCKyio CUCTeMy OT TKaHeH opraHa. /5/ :

HnMMyHOMOZyAUpyouUe CBOUCHMBa HEKOMOPHX I'OPMOHOB

- TecmocmepoH (aHOpPO2eHH )
AHAPOreHbH cynpeccupyioT T- ¥ B-3aBHUCHMbII HWMMYHHHIA OTBEeT M
PaKTHYECKH BCerpa MNpUBOASIT K [OAAB/ISHHUIO BHPAXEHHOCTU OONE3HH.
-- CynpeccupyeT OOJBIMHCTBO BHJAOB HWMMYHHOH AaKTHUBHOCTH. B
KneTKaxXx ceJle3eHKH KaCTpUPOBAHHLIX XHUBOTHBX MOBHUIIAETCS CHUH-
Te3 aHTUTeJl. lerMApOTecTOCTEepPOH TOPMO3UT CHHTe3 W/N-4, WUMI-5
M UP-raMMa aKTHBHPOBAaHHHMHU 3peqabiMu T-kKaeTkaMu 6e3 Bozjgenc-
TBUSI Ha Nponyxkuuw HMA-2. /2

-- Ha nepudepun aHaporeHs MNOBHBAKOT aAaKTUBHOCTL CD8 kjaeTok. /2/

-- TeCTOCTepOH NOoBHIlAeT CHHTEe3 anbdpa-1-aHTUTPUIICHHA, OPO3OMYy~—
Kouzaa, ranrorqiobuHa. /6/

- JlomeuHu3upybiull 20pMOH-puUAU3UH2 Pakmop /LHRH/

pery/siupyeT QyHKLHWOHa/bHY akTHUBHOCTb THUMyca, crnocobcTBysa ne-

Egg$gonis/oprauusma B TeYeHUe MEeHCTPpyaJlbHOTrO UuK/ja U OepeMeH-

BeigB/eHa axcngeccafl reda LHRH-R nva saumbpouyurax. /7/

- posakmus (prolactin; PRL; /OTEOTPONHHA COpMOH) - FOPMOH ne-
peiHen Joad runogpusza
-- IllposiBaAdgeT MMMYHOCTUMYJAMUpyoOIHEe cBowicTBa. /8/

4

KOHLIeHTpaUus MNposiaKTHHA MNOBLUWAETCs NPHA OTTOPXEHWH TpaHC-
nanaHrara (ceppua). /8/

-~ [lpelnooXrMTe/lbHO MOXeT KOHTPO/UpOBaTh AKTHBHOCTbL ayTOWMM-
MyHHBIX HonesHen. /8/

- [IpocecmepoHd (XEHCKWA CTEepOMAHLHN NOMOBOW I'OPMOH)

-~ WMMyHOCYIpeCCHBHbE, MPOTHUBOBOCNA/NMTE/bHHEe CBOWUCTBA
[l[poTecCTEpOH B BHCOKHMX KOHLEHTpaLUsiX MHUMEeTHpyeT TJI0KOKOPTH-
KouaHse 3PpbeKkThH B CH/AY HU3KOABUIAHOrO CBS3HBaHWUA C pelenTo-
paMM KopTuzona. /1/ »

--- 0ObnagaeT NPOTUBOBOCHAJAMTE/IbHBIMU CBOWMCTBAMH
--—-- CHUXaeT obOpa3oBaHUe KWUCJ/ICPOJHHX paJMKa/lOoB Makpo-
daramm.
---- JlogaBJjsseT NpPOAYKLMIO Un-1-6eta, HP-ramMma JauMbouLU-
TaMH.
---- CHUuXaeT npoaykuuio U/1-8 YesoBeYeCKHWMH DHIAOMETpU-
anbHBIMU KJETKaMHu.
--—-~ UHTUMOHMpyeT npoaykuuvo WU/1-6 peunayasJbHbBMA CTpPOMaJb-
HBIMH KJ/I€TKaMK 4YesioBeKa B KyJbType.
--- WHAYyLUMpPYEeT CHUHTe3 JMMPOLMTAMH HMMYHOCYNPEeCCHUBHOIO (akx-
Topa (npeporBpamawiero adopT).

NuMPpouuTs OGepeMEHHBX XEHMHH, CcOJepxaude peHenTOpH AAdA
nporecrepoHa, B MPUCYTCTBHU TOPMOHA CEKPEeTHDYKT OEAOK
¢N. 34K]]l - NPOTECTEPOH-32BHCHMHA O6NOKHPYDUHH GakToOp
(M3B®). YcnewHOMY MHCX0AY OGEepEeMEHHOCTH cnocobcTBYET
N36¢ u UA-10.

--- [lporectepodH HHrubupyeT OTBET JIMMPOLUHMTOB Ha MUTOTEHH M
anfoaHTUreHs, a TakxXe cnocobeH npojneBaTh BpeMsi BBXH-
BaHUsl TpaHCcIviaHtara. /9/

--- [lporecTepoH MMeeT HeNpsMoe BJAUSHME Ha aKTUBHOCTb EKK.
flgorecrepon—uunyuupOBaHHufi Snoxupyouun daxkTop (PIBF)
(besioK, KOTOPHMW oONoOCpefpyeT MWMMYHOJOTWYECKHe I0deKTH
nporecrepoHa), OaoxkupyeT aKTUBHOCTh EKK 1n vitro u
npepoTrBpayjaeT BHKUABI EaSOpTHBHHfi 30deKT) NpyM BHCOKOH
akTuBHOCTU EKK y mbumen. [JloBHUleHHAad aKTUBHOCTb EKK MO-
XeT MrpaTh posib B npepbhBaHuu OepemeHHocTH; PIBF, no-
NaBJsoOIUA KK, MoxeT cnocofcTBOBaTh NOAJepXaHHUI0O HOp-
MaJ/IbHOM recrtauuu (OepeMeHHOECTH). /2/

B KOHLeHTpauuax, NpoAyUUPYyeMbX JIOKa/JbHO B IUalleHTapHO-Ma-

TEPUHCKOA HHTepdase, IMPOrecTepOH MOXeT BKJ/OYAaTbCA B MexXa-

HM3M NpejoTBpalleHyWs npepbBaHus SepeMeHHOCTU. /2/

- OcmpozeHH {3CTpajgvof, 3CTPOH, 3CTPHUOJ) - XEHCKHe MOoJOBhe CTe-
POMIHbE TIOPMOHB, KOHLEHTpaLUUs KOTOPHX MOBHaeTcs nNpu OepeMeH-
HOCTH. ;

-~ WUMMyHOMOZY/JHUPYOlIHEe CBONCTBA

l1alleHTapHbe 3CTpajguosab TOPMO3AT MMMYHHBA OTBET y MaTepH,

yToO n??g?nfler COXpPaHUTh I[JIOJ OT HEeHYXHOW HWMMYHHOHW arpec-

CHUH.

--~ BCTPOTreHH TOPMO3AT KJAeTOoYHBH (Thl-3aBUCHUMBIA) W CTUMYy-
AUpywT ryMmMopanbHbil (Th2-3aBHCHMBA) UMMYHHBIA OTBeT.

NlporecTepoOH H 3CTPajHON NpY OGEPEMEHHOCTH H B JOTEHHO-
By® $a3y MEHCTPYAaAJAbBHOI'O I[HMKJA YYacTBY®WT B NEPEKINYEHHH
UHTOKHUHOBOIro npoduasd npud MMMYHHOM OTBETE HAa Th2 THN.
Lododi £

DCTPOTreHs MOBHUWAKNT NPOAYKLUUIO aHTUTes, ycyrybsnass B-3za-
BUCUMbe O0osie3HU YesioBeKa. /12

~--=- BcTporeH (B NOBbHIWEHHONW KOHLUEHTPAallWHk) Bbi3bBaeT HHBOJO-
LMo TUMyca M nepupepuHdiecKux nnngonnflmx opraHos. /9/

~--- YMeHbuwawT 6NacTTPAHCPOPMUDYWUYO CHOCOOHOCTD T-NHMQOLH-
TOB (OTBE€T HA MUTOCEHH) .

~--~ JCTpazuoAn YCUAUBAET AaKTHBHOCTSH ECTECTBEHHBHX KJe-
TOK-KuanepoB /EKK/, OAHAaKo nocsae 30-AHEBHOI'0 BBEJAEHHSA
akKTHUBHOCTh EKK CHHXxXaeTcH, YTO CBA3bHBAKT CO 3HAYHUTENADL -
HO®M anjas3ded KOCTHOIO MOo3ra. YCTaHOBINEHO HalWyHe 0606-
PATHOM KOpPppPEJASUHM MEXAY YPOBHEM AKTUBHOCTH EKK WU KOH-
HeHTpalHeH 3cTpajiHoJa B HJAa3MEe KpOBU NpH OEPEMEHHOCTH
nNo Mepe ee NporpeccHpoOBAaHHSA.

--- U3BBITOK DCTPOreHOB CHHXaeT %CTOQQMBOCTB K ONyXOJsiM H
napazutaM. JCcTporeHs uMenT JHK-noBpexpawomuid 3Q0eKT.
-- DCTporeHs NoBHUWAKT CcooTHomeHue CD4/CD8.

WNO3CTPOrEHU3M, BH3BAHHHH XHUDYpPrHYeCcKHM NYTEeN Yy XCHWHH B
NpeMeHoNnay3y, NPHBOJAMT K CHUXKEHHNM COooOTHouweHus CD4/CD8., Xo-

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